The KSI vs. Dillon Danis matchup has once again failed to make it to the ring.

Next weekend was set to see the pair's longtime rivalry finally settled in the main event of Misfits Boxing 21 in Manchester, England. It was to come just over two years on from their first attempt at sharing the squared circle, which collapsed when Danis withdrew citing unpreparedness.

The bout has once again been postponed, but this time due to an issue on the side of the YouTuber-turned-boxer.

It emerged on Friday, eight days out from the planned event inside the AO Arena, that an illness to KSI has rendered him unable to compete. The Englishman confirmed the news himself in a video posted to the Misfits Boxing X account.

With the high-profile main event off, the entire event has also been delayed.

That means a canceled return for ex-UFC title challenger Darren Till, who was slated to co-headline the March 29 card opposite another former Octagon veteran in Darren Stewart.

KSI hasn't boxed since a decision defeat to Tommy Fury in October 2023. Dillon Danis, meanwhile, fell short to Logan Paul on the same night.

Rebooking the seemingly cursed matchup between the bitter foes could prove tricky, with the American former Bellator fighter expected to make his MMA return to face Tony Ferguson under the Global Fight League banner in either May or June.